A Paper entitled "Urinary Fetuin-A Is a Novel Marker for Diabetic Nephropathy in Type 2 Diabetes Identified by Lectin Microarray"

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As far as we know, this paper will be the first study to perform glycan profiling of urines samples from the patients with diabetic nephropathy. As a result of their glycan profiling study using lectin microarrays, they found global reduction of the bindings to lectins, such as fucose, Lac/LacNA, α- or β-Gal, chitobiose, and α- or β-GalNAc binders in urine samples of diabetic nephropathy at macroalbuminuria stage. Unlike the reduced bindings to these lectins, interestingly the biding activity to Siaα2-6-Gal/GalNAc binders progressively increased at micro- and macroalbuminruia stages.

Then, by capturing Siaα2-6Gal/GalNAc modified glycoproteins with SNA- and SNA-agarose column chromatography, they finaly concluded that higher urinary fetuin-A excretion demonstrated a higher risk for the development of microalbuminuria and reduction of renal function.

Urinary Fetuin-A Is a Novel Marker for Diabetic Nephropathy in Type 2 Diabetes Identified by Lectin Microarray

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このページは、Adminが2013年10月21日 13:34に書いたブログ記事です。

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