• 薬剤耐性HIVと糖鎖
    Giron LB, Tanes CE, Schleimann MH, Engen PA, Mattei LM, Anzurez A, Damra M, Zhang H, Bittinger K, Bushman F, Kossenkov A, Denton PW, Tateno H, Keshavarzian A, Landay AL, Abdel-Mohsen M. Sialylation and fucosylation modulate inflammasome-activating eIF2 Signaling and microbial translocation during HIV infection. Mucosal Immunol. 2020 Mar 9. doi: 10.1038/s41385-020-0279-5.
  • 放射線と糖鎖
    D. Iizuka, S. Izumi, F. Suzuki, and K. Kamiya, Analysis of a lecin microarray identifies altered sialylation of mouse serum glycoproteins induced by whole-body radiation exposure, J. of Radiation Research, rry100, https://doi.org/10.1093/jrr/rry100.
  • うつ病と糖鎖
    H. Yamagata, S. Uchida, K. Matsuo, K. Harada, A. Kobayashi, M. Nakashima, F. Higuchi, T. Watanuki, T. Matsubara, and Y. Watanabe, Altered plasma protein glycosylation in a mouse model of depression and in patients with major depression, J. of Affective Disorders, June 2018, Vol.233, pp-79-85, https://doi.org/10.1016/j.jad.2017.08.057.
  • エクソソームの糖鎖プロファイリング
    A. Shimoda, Y. Tahara, S. Sawada, Y. Sasaki, and K. Akiyoshi, Glycan profiling analysis using evanescent-field fluorescence-assisted lectin array: Importance of sugar recognition for cellular uptake of exosomes from mesenchymal stem cells., BBRC, 2017 Sept. 23, 491(3)pp701-707. doi:10.1016/j.bbrc.2017.07126.
  • 糖鎖マッピング
    X. Zou, M. Yoshida, C. Nagai-Okatani, J. Iwaki, B. Tan, K. Hagiwara, T.Sato, Y. Itakura, E.Noro, H. Kaji, M. Toyoda, Y. Zhang, H. Narimatsu, and A. Kuno, A stadardized method for lectin microarray-based tissue glycome mapping, Sci. Rep., 2017 Mar 6;7:43560. doi: 10.1038/srep43560.
  • 大腸がん再発と糖鎖
    K. Nakajima, M. Inomata, H. Iha, T. Endoh, N. Shiraishi, K. Kashima, and S. Kitano, Establishment of new predictive markers for distant recurrence of colorectal cancer using lectin microarray analysis, Cancer Med., 2015 (Feb); 4(2): 293-302. doi: 10.1002/cam4.342.
  • 胃がん再発と糖鎖
    T. Futsukaichi, T. Etoh, K. Nakajima, T. Daa, H. Shiroshita, N. Shiraishi, S. Kitano, and M. Inomata, Decreased expression of Bauhinia purpurea lectin is a predictor of gastric cancer recurrence, Surg Today, 2015 Oct; 45(10): 1299-306. doi: 10.1007/s00595-015-1127-1.
  • フコース化と膵管内乳頭粘液性腫瘍
    K. Watanabe, M. Ohta, K. Yoda, Y. Komori, Y. Iwashita, K. Kashima, and M. Inomata, Fucosylation is associated with the malignant transformation of intraductal papillary mucinous neoplasms: a lectin microarray-based study, Surg Today, 2016 Oct; 46(10): 1217-23. doi: 10.1007/s00595-015-1299-8.
  • 免疫応答と糖鎖
    M. Yamamoto-Hino, M. Muraoka, S. Kondo, R. Ueda, H. Okano, and S. Goto, Dynamic regulation of innate immune responses in Drosophia by Senju-mediated glycosylation, Proc. Natl Acad Sci USA, 2015 May 5; 112(18): 5809-14. doi:10.1073/pnas.1424514112.
  • Biobetter Characterization
    M. Roucka, K.Zimmermann, M. Fido, and A. Nechansky, Application of Lectin Array Technology for Biobetter Characterization: Its Correlation with FcyRIII Binding and ADCC, Microarrays 2017, 6(1); doi:10.3390/microarrays6010001.
  • Muchin-Like Glycopeptides
    G. Artigas, H. Hinou, F. G. Martin, H. J. Gabius, and S. Nishimura, Synthetic Mucin-Like Glycopeptides as Versatile Tools to Measure Effects of Glycan Structure/Density/Position on the Interaction with Adhesion/Growth-Regulatory Galectins in Arrays, Chem. An Asian Journal, DOI: 10:1002/asia.201601420.
  • MUC1のO型糖鎖と癌
    A. Matsuda, A. Kuno, T. Nakagawa, Y. Ikehara, T. Irimura, M. Yamamoto, Y. Nakamura, E. Miyoshi, S. Nakamori, H. Nakanishi, C. Viwatthanasittiphong, P. Srivatanakul, M. Miwa, J. Shoda, and H. Narimatsu, Lectin Microarray-Based Sero-Biomarker Verfication Targeting Aberrant O-Linked Glycosylation on Mucin 1, Anal Chem, 2015 Jul 21; 87(14):7274-81. doi: 10.1021/acs.analchem.5b01329. Epub 2015 Jul 7.
  • 進行性胃がんのリンパ節転移
    K. Yamashita, A. Kuno, A. Matsuda, Y. Ikehara, N. Katada, J. Hirabayashi, H. Narimatsu, M. Watanabe, Lectin Microarray technology identifies specific lectins related to lymph node metastasis of advanced gastric cancer, Gastric Cancer, 2015 Apr.4, PMID: 25840959
  • 癌診断
    H. Narimatsu, Synthesiology – English edition Vol.5, No.3, p.201 (Dec. 2012)
  • 絨毛癌の糖鎖プロファイリング
    Y. Kobayashi, K. Masuda, K. Banno, N. Kobayashi, K. Umene, Y. Nogami, K. Tsuji, A. Ueki, H. nomura, K. Sato, E. Tominaga, T. Shimizu, H. Saya, and D. Aoki, Glycan profiling of gestational choriocarcinoma using a lectin microarray.
  • 糖尿病性腎症と糖鎖マーカー
    K. Inoue, J. Wada, J. Eguchi, A. Nakatsuka, S. Teshigawara, K. Murakami, D. Ogawa, T. Terami, A. Katayama, A. Tone, I. Iseda, K. Hida, M. Yamada, T. Ogawa, and H. Makino, Urinary Fetuin-A is a Novel Marker for Diabetic Nephropathy in Type 2 Diabetes Identifies by Lectin Microarray.
  • レクチンアレイと診断薬
    A. Kuno, T. Sato, H. Shimazaki, S. Unno, K. Saitou, K. Kiyohara, M. Sogabe, C. Tsuruno, Y. Takehama, Y. Ikehara, and H. Narimatsu, Reconstruction of a robust glycogiagnostic agent supported by multiple lectin-assisted glycan profiling, Proteomics Clin Appl., 2013 May3, doi: 10.1002/prca.201300010.
  • 胆管癌の癌マーカー
    A. Matsuda, A. Kuno, H. Matsuzaki, T. Kawamoto, T. Shikanai, Y. Nakanuma, M. Yamamoto, N. Ohkohchi, Y. Ikehara, J. Shoda, J. Hirabayashi, and H. Narimatsu, Glycoproteomics-based cancer marker discovery adopting dual enrichment with WFA for high specific glyco-diagnosis of cholangiocarcinoma, J. of Proteomics 85 (2013) p.1-11.
  • 肝細胞癌の癌マーカー
    H. Kaji, M. Ocho, A. Togayachi, A. Kuno, M. Sogabe, T. Ohkura, H. Nozaki, T. Angata, Y. Chiba, H. Ozaki, J, Hirabayashi, Y. Tanaka, M. Mizokami, Y. Ikehara, and H. Narimatsu, J. of Proteome Res., 2013, 12 p.2630-2640.
  • 網膜の糖鎖プロファイリング
    Lectin Microarray Profiling and Relative Quantification of Glycome Associated With Proteins of Neonatal wt and rd1 Mice Retinae, S. Ahuja, Invest Ophathalmol Vis Sci. 2013 May 7; 54(5): 3272-80. doi: 10.1167/iovs.12-11363.
  • 膵島の異種移植と糖鎖
    A lectin array analysis for wild-type and α-Gal-knockout pig islets versus healthy human islets, S. Miyagawa, A. Maeda, S. Takeishi, T. Ueno, N. Usui, S. Matsumoto, T. Okitsu, M. Goto, and H. nagashima, Surg Today, 2013 Apr.3.
  • 成人T細胞白血病と糖鎖プロファイリング
    Glycan Profiling of Adult T-Cell Leukemia (ATL) Cells with the High Resolution Lectin Microarrays, H. Iha and M. Yamada, “T-Cell Leukemia – Characteristics, Treatment and Prevention”, book edited by Mariko Tomita, ISBN 978-953-51-0996-9, Published: February 20, 2013 under CC BY 3.0 license, DOI: 10.5772/55386.
  • 肝臓線維化糖鎖マーカー
    A serum “sweet-doughnut” protein facilitaes fibrosis evaluation and therapy assessment in patients with viral hepatitis, A. Kuno, Y. Ikehara, Y. Tanaka, K. Ito, A Matsuda, S. Sekiya, S. Hige, M. Sakamoto, M. Kaga, M. Mizokami and H. Narimatsu, Scientific Reports 3, Article number: 1065, doi:10.1038/srep01065.
  • iPS細胞の特徴的な糖鎖構造変化
    Structural and quantitative evidence for dynamic glycome shift on production of induced pluripotent stem cells, K. Hasehira, H. Tateno, Y. Onuma, Y. Ito, M. Asashima, and J. Hirabayashi, Mol Cell Proteomics., 2012 Dec;11(12):1913-23. doi: 10.1074/mcp.M112.020586.
  • 子宮内膜癌の悪性度
    Glycan profiling of endometrial cancers using lectin microarray, Y. Nishijima, M. Toyoda, M. Yamazaki-Inoue, T. Sugiyama, M. Miyazawa, T. Muramatsu, K. Nakamura, H. Narimatsu, A. Umezawa, and M. Mikami, Genes Cells, 2012 Oct. 17(10):826-36. doi: 10.1111/gtc. 12003.
  • 癌の転移と糖鎖変化
    Lectin array-based strategies for identifying metastasis-associated changes in glycosylation, S. Fry, B. Afrough, A. Leathem, and M. Dwek, Methods Mol Biol., 2012;878:276-72
  • バレット食道
    Molecular imaging using fluorescent lectins permits rapid endoscopic identification of dysplasia in Barrett’s esophagus, Bird-Lieberman EL, Neves AA, Lao-Sirieix P, O’Donovan M, Novelli M, Lovat LB, Eng WS, Mahal LK, Brindle KM, Fitzgerald RC., Nature Med. 2012 Jan 15. doi: 10.1038/nm.2616.
  • iPSへの応用
    Specific lectin biomarkers for isolation of human pluripotent stem cells identified through array-based glycomic analysis, YC. Wang, M. Nakagawa, I Garitaonandia, I. Slavin, G. Altun, RM Lacharite, KL Nozor, HT Tran, CL Lynch, TR Leonardo, Y. Lue, SE Peterson, LC Laurent, S. Yamanaka, and JF Loring, Cell Res. 2011 Nov;21(11):1551-63. doi: 10.1038/cr.2011.148. Epub 2011 Sep 6.
  • 肝臓繊維化検査用レクチン・抗体サンドイッチアッセイ:
    LecT-Hepa: A triplex lectin-antibody sandwich immunoassay for estimating the progression dynamics of liver fibrosis assisted by a bedside clinical chemistry analyzer and an automated pretreatment machine, A. Kuno, Y. Ikehara, Y. Tanaka, K.Saito, K. Ito, C. Tsuruno, S. Nagai, Y. Takahama, M. Mizokami, J. Hirabayashi, and H. Narimatsu, Clinica Chimica Acta 412 (2011) 1767-1772.
  • レクチンアレイを用いたPSGL-1/mIgGのプロファイリング:
    Pichia pastoris-produced mucin-type fusion proteins with multivalent O-glycan subsitution as targeting molecules for mannose-specific receptors of the immune system, A. Gustafsson, M. Sjoblom, L. Strindelius, T. Johansson, T. Fleckenstein, N. Chatzissavidou, L. Lindberg, J. Angstrom, U. Rova, and J. Holgersson, Glycobiology, 2011 Aug. 21(8), 1071-1086.
  • アルツハイマーと水頭症の糖鎖マーカー:
    A unique N-glycan on human transferrin in CSF: a possible biomarker for iNPH, S. Futakawa, K. Nara, M. Miyajima, A. Kuno, H. Ito, H. Kaji, K. Shirotani, T. Honda, Y. Tohyama, K. Hoshi, Y. Hanzawa, S. Kitazume, R. Imamaki, K. Furukawa, K. Tasaki, H. Arai, T. Yuasa, M. Abe, H. Arai, H. Narimatsu, and Y. Hashimoto, Neurobiol Aging. 2011 Apr 1. [Epub ahead of print]
  • MSC, ES, iPS細胞のレクチンマイクロアレイによる評価:
    Lectin microarray analysis of pluripotent and multipotent stem cells, M. Toyoda, M. Yamazaki-Inoue, Y. Itakura, A. Kuno, To. Ogawa, M. Yamada, H. Akutsu, Y. takahashi, S. Kanzai, H. Narimatsu, J. Hirabayashi, and A. Umezawa, Genes to Cells, Vol.16, Issue 1, 1-11, January (2011), DOI: 10.1111/j.1365-2443.2010.01459.x
  • 細胞表面グライコームの幹細胞評価における重要性:
    Potential Linkages Between the Inner and Outer Cellular States of Human Induced Pluripotent Stem Cells, S. Saito, Y. Onuma, Y. Ito, H. Tateno, M. Toyoda, H. Akutsu, K. Nishino, E. Chikazawa, Y. Fukawatase, Y. Miyagawa, H. Okita, N. Kiyokawa, Y. Shimma, A. Umezawa, J. Hirabayashi, K. Horimoto, and M. Asashima, ISB2010, Suzhou, China, September 9-11, 2010, pp.381-388.
  • 胆管癌の新糖鎖バイオマーカー:
    Wisteria floribunda Agglutinin-Positive Mucin 1 is a Sensitive Biliary Marker for Human Cholangiocarcinoma, A. Matsuda, A. Kuno, H. Matsuzaki, T. Irimura, Y. Ikehara, Y. Zen, Y. Nakamura, M. Yamamoto, N. Ohkuhchi, J. Shoda, J. Hirabayasi, and H. Narimatsu, Hepatology. 2010 Jul;52(1):174-82.
  • ブタ臓器の移植:
    S. Miyagawa, S. Takeishi, A. Yamamoto, K. Ikeda, H. Matsunari, M. Yamada, M. Okabe, E. Miyoshi, M. Fukuzawa, and H. nagashima, Xenotransplantation, 2010 Jan. Vol 17(1), pp.61-70.
  • IL23R-Fc proteinの糖鎖構造と活性:
    Transient expression of an IL-23R extracellular domain Fc fusion protein in CHO vs. HEK cells results in improved plasma exposure, K. F. Suen, M. S. Turner, F. Gao, B. Liu, A. Althage, A. Slavin, W. Ou, E. Zuo, M. Eckart, T. Ogawa, M. Yamada, T. Tuntland, J. L. harris, and J. W. Trauger, Protein Expr. Purif. (2010), doi:10.1016/j.pep.2009.12.015.
  • バイオマーカー探査の方法論:
    A Strategy for discovery of cancer glyco-biomarkers in serum using newly developed technologies for glycoproteomics, H. Narimatsu, H. Sawaki, A. Kuno, H. Kaji, H. Ito, and Y.Ikehara, FEBS Journal (2009), doi:10.1111/j.1742-4658.2009.07430.x
  • tACEのGPIase活性:
    Testicular Angiotensin-Converting Enzyme with Different Glycan Modification: Characterization on Glycosylphosphatidylinositol-Anchored Protein Releasing and Dipeptidase Activities, G. Kondoh, Ho. Watanabe, Y. tashima, Y. Maeda, and T. Kinoshita, J. Biochem. 2009 145(1)115-121, doi:10.1093/jb/mvn148.
  • 肝臓幹細胞のマーカー探査:
    High levels of E4-PHA-reactive oligosaccharides: potential as marker for cells with characteristics of hepatic progenitor cells, N. Sasaki, K. Moriwaki, N.Uozomi, K. Noda, N. Taniguchi, A. Kameyama, H. Narimatsu, S. Takeishi, M. Yamada, N. Koyama, and E. Miyoshi, Glyconj J., DOI 10.1007/s10719-009-9240-2, May (2009).
  • グライコプロテオミクスの方法論:
    Strategy for Glycoproteomics: Identification of Glyco-Alteration Using Multiple Glycan Profiling Tools (dagger), H. Ito, A. Kuno, H. Sawaki, M. Sogabe, H. Ozaki, Y. Tanaka, M. Mizokami, JI. Shoda, T. Angata, T. Sato, J. Hirabayashi, Y. Ikehara, and H. Narimatsu., J Proteome Res., Mar 6;8(3), pp.1358-1367 (2009).
  • 高感度化の最適化:
    Optimization of evanescent-field fluorescense-assisted lectin microarray for high-sensitive detection of monovalent oligozaccharides and glycoproteins, Noboru Uchiyama, Atsushi Kuno, Hiroaki Tateno, Yoshiko Kubo, Mamoru Mizuno, Midori Noguchi, and Jun Hirabayashi, Proteomics Vol.8, p.3042 (2008).
  • 細胞糖タンパク質のディファレンシァルプロファイリングのためのデータマイニングシステム:
    Development of a data-mining system for differential profiling of cell glycoproteins based on lectin microarray, Atsushi Kuno, Yoko Itakura, Masashi Toyoda, Yoriko Takahashi, Masao Yamada, Akihiro Umezawa, and Jun Hirabayashi, Journal of Proteomics & Bioinformatics(JPB), Vol.1, p.68 (2008.5). 詳細ダウンロード:834KB
  • ホルマリン固定組織切片の糖鎖プロファイリング:
    Development of an all-in-one technology for glycan profiling targeting formalin-embedded tissue sections, Atsushi Matsuda, Atsushi Kuno, Hiroyasu Ishida, Toru Kawamoto, Jun-ichi Shoda and Jun Hirabayashi, Biochemical and Biophysical Research Communications,370, p.259 (2008).
  • 糖鎖プロファイリングの時代到来:
    The Era of Glycan Profiling has come: Glycomics’s Infinite Potential and Applications to Healthcare, M. Yamada, GOR, Vol.9, No.1, p.16 (2007). 詳細ダウンロード:2.3MB
  • 分子間相互作用ハンドブック タンパク質とタンパク質・核酸・糖・脂質・低分子間のネットワーク解析(礒辺俊明,中山敬一,伊藤隆司/羊土社/2007.9)
    第4章1項 レクチンアレイによる糖タンパク質の解析【久野 敦 平林 淳】
  • 抗体オーバーレイ レクチンマイクロアレイの測定:
    Inhibition of tumor cell-induced platelet aggregation using a novel anti-podaplanin antibody reacting with its platelet-aggregation-stimulating domain, Y. Kato, M. K. Kaneko, A. Kuno, N. Uchiyama, K. Amano, Y. Chiba, Y. Hasegawa, J. Hirabayashi, H. Narimatsu, K. Mishima, and M. Osawa, doi:10.1016/j.bbrc.2006.08.171.
  • クルードサンプルのアプリケーション:
    Application of Lectin Microarray to Crude Samples: Differential Glycan Profiling of Lec Mutants: Youji Ebe, Atsushi Kuno, Noboru Uchiyama, Shiori Koseki-Kuno, Masao, Takashi Sato, Hisashi Narimatsu and Jun Hirabayashi, J Biochem, 139(3), p.323 (2006).
  • フロンタルアフィニティークロマトグラフィー(FAC):
    High-throughput analysis of lectin-oligosaccharide interactions by automated frontal affinity chromatography, Methods, S. Nakamura-Tsuruta, N. Uchiyama, and J. Hirabayashi, Enzymol., Vol.415, p.311 (2006).
  • 糖鎖プロファイリング技術の原理と性能:
    Evanescent-field fluorescence-assisted lectin microarray: a new strategy for glycan profiling: Atsushi Kuno, Noboru Uchiyama, Shiori Koseki-Kuno1, Youji Ebe, Seigo Takashima, Masao Yamada & Jun Hirabayashi, Nature Methods Vol.2, No.11, p.851 (2005).